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KMID : 1036920200250040240
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Annals of Pediatric Endocrinology & Metabolism
2020 Volume.25 No. 4 p.240 ~ p.247
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Discriminatory performance of insulin-like growth factor 1 and insulin-like growth factor binding protein-3 by correlating values to chronological age, bone age, and pubertal status for diagnosis of isolated growth hormone deficiency
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Choi Yu-Jung
Lee Yoon-Ji
Lee Na-Yeong
Lee Seon-Hwa
Kim Seul-Ki
Ahn Moon-Bae
Kim Shin-Hee
Cho Won-Kyoung
Cho Kyoung-Soon
Jung Min-Ho
Suh Byung-Kyu
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Abstract
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Purpose: The discriminatory performance of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) was investigated by correlating their values with chronological age (CA), bone age (BA), and pubertal status (PS) for diagnosis of isolated growth hormone deficiency (IGHD).
Methods: We evaluated IGF-1 and IGFBP-3 levels in 310 short-stature subjects subdivided into 2 groups: IGHD (n=31) and non-IGHD (n=279). IGF-1 and IGFBP-3 were assayed using immune-radiometric assay and transformed into standard deviation score (SDS) according to CA, BA, and PS.
Results: The highest sensitivity was found in IGF-1-SDS for CA and IGFBP-3-SDS for CA (22.6% and 30.0%, respectively). The highest specificity was found in IGF-1-SDS for PS and IGFBP-3-SDS for PS (98.2% and 94.4%, respectively). Groups with the highest positive predictive values were IGF-1-SDS for BA and IGFBP-3-SDS for BA (10.9% and 5.1%, respectively). Highest negative predictive values were seen in IGF-1-SDS for CA and IGFBP-3-SDS for CA (98.4% and 98.4%, respectively).
Conclusions: IGF-1-SDS for CA, instead of IGF-1-SDS for BA or PS, could be used as a standard variable for IGHD screening. The sufficiently high specificity of IGF-1-SDS for PS suggests that this value is a useful tool for identification of IGHD.
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KEYWORD
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Insulin-like growth factor 1, Insulin-like growth factor binding protein-3, Isolated growth hormone deficiency, Sensitivity, Specificity, Chronological age, Bone age, Pubertal status
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